By J. Knoll and K. Kelemen (Eds.)
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Additional resources for Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
The use of beta-adrenergic receptor blocking drugs in dysrhythmias. Prog. Cardiovasc. : Propranolol therapy in patients with acute myo cardial infarction: the beta-blocker heart attack trial. : Short term risk factors for sudden death. Ann. NY Acad. B. : Sudden coronary death: the Framingham study. Ann. NY Acad. , Kostuk, W. : Effects of intravenously administered propranolol on wall mo tion abnormalities. Amer. J. , Vigano, A. : Non-invasive assessment of left ventricular ana tomy and function in hypertensive patients following successful treatment of hypertension with the beta-adrenergic blocking drug atenolol.
E. in the anesthe tized dog with critical stenosis of the LAD ischaemic ST-seg ment elevation could be evoked by standardized high rate pacing in the epi-, endo- and intramyocardial electrogramm recorded from the area distal to the site of stenosis. l. v. injection of 30 mg/kg SP and manifested by a diminution of the ST-segment in the epicardial electrogram elevated by pacing the heart above the sponta neous rate. This antiischaemic effect temporally exactly coin cided with the maximal inhibition of ex vivo platelet aggre gation.
Primary VF is reversible, it can be treated and prevented /Julian, 1976/. It may appear on the basis of an electrical instability of the heart predisposing to ventricular arrhythmias. Instability mostly arises on account of a chronic heart disease and is ma nifested by biochemical, morphological and electrophysiologi cal inhomogeneity of the myocardial fibers. It is assumed that in addition to instability a precipitating factor is needed which may disrupt the normal sequence of cardiac contractions and start self-sustaining dysrhythmic activity ending in fatal VF.
Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985 by J. Knoll and K. Kelemen (Eds.)