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By J. Knoll and K. Kelemen (Eds.)

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Additional resources for Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985

Example text

The use of beta-adrenergic receptor blocking drugs in dysrhythmias. Prog. Cardiovasc. : Propranolol therapy in patients with acute myo­ cardial infarction: the beta-blocker heart attack trial. : Short term risk factors for sudden death. Ann. NY Acad. B. : Sudden coronary death: the Framingham study. Ann. NY Acad. , Kostuk, W. : Effects of intravenously administered propranolol on wall mo­ tion abnormalities. Amer. J. , Vigano, A. : Non-invasive assessment of left ventricular ana­ tomy and function in hypertensive patients following successful treatment of hypertension with the beta-adrenergic blocking drug atenolol.

E. in the anesthe­ tized dog with critical stenosis of the LAD ischaemic ST-seg­ ment elevation could be evoked by standardized high rate pacing in the epi-, endo- and intramyocardial electrogramm recorded from the area distal to the site of stenosis. l. v. injection of 30 mg/kg SP and manifested by a diminution of the ST-segment in the epicardial electrogram elevated by pacing the heart above the sponta­ neous rate. This antiischaemic effect temporally exactly coin­ cided with the maximal inhibition of ex vivo platelet aggre­ gation.

Primary VF is reversible, it can be treated and prevented /Julian, 1976/. It may appear on the basis of an electrical instability of the heart predisposing to ventricular arrhythmias. Instability mostly arises on account of a chronic heart disease and is ma­ nifested by biochemical, morphological and electrophysiologi­ cal inhomogeneity of the myocardial fibers. It is assumed that in addition to instability a precipitating factor is needed which may disrupt the normal sequence of cardiac contractions and start self-sustaining dysrhythmic activity ending in fatal VF.

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Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985 by J. Knoll and K. Kelemen (Eds.)


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