By Philip M. Parker
In March 2001, the nationwide Institutes of overall healthiness issued the next caution: ''The variety of sites delivering health-related assets grows each day. Many websites supply important info, whereas others can have info that's unreliable or misleading.'' additionally, as a result of fast elevate in Internet-based details, many hours should be wasted looking out, choosing, and printing. given that basically the smallest fraction of data facing Amyotrophic lateral sclerosis is listed in se's, comparable to www.google.com or others, a non-systematic method of net examine should be not just time eating, but additionally incomplete. This booklet was once created for doctors, scholars, and individuals of most people who are looking to behavior scientific learn utilizing the main complex instruments on hand and spending the smallest amount of time doing so.
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Extra info for Amyotrophic Lateral Sclerosis - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers
Professor & Vice Chairman; Neurology; University of Pittsburgh at Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260 Timing: Fiscal Year 2004; Project Start 01-JUN-1999; Project End 31-MAY-2008 Summary: (provided by applicant): Cyclooxygenase, the enzyme that catalyzes the production of prostaglandins from arachidonic acid, has long been thought to play a 36 Amyotrophic Lateral Sclerosis role in exacerbating injury due to cerebral ischemia via its vascular and inflammatory effects. Recently it has been found that the inducible isoform of the enzyme, cyclooxygenase 2 (COX2), is expressed in high levels within neurons.
Reluctant vesicles may be present at a distinct set of presynaptic terminals from willing vesicles or may arise within terminals as a result of stimulus-dependent factors. We propose to study the mechanisms and regulation of reluctant vesicles. We hypothesize a rapid-onset, calciumdependent feedback mechanism is particularly important in vesicle reluctance. The second synaptic adaptation is a persistent change in glutamate vesicle availability that outlives the inducing stimulus. We show that normal action potential activity suffices to inactivate a small percentage of glutamate vesicles, and that the number of inactivated vesicles is increased by augmenting neuronal activity.
2005 Sep 27;65(6):820-5. Epub 2005 Aug 10. PubMed citation • Wirth B, Brichta L, Schrank B, Lochmuller H, Blick S, Baasner A, Heller R. Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number. Hum Genet. 2006 May;119(4):422-8. Epub 2006 Mar 1. PubMed citation • Wirth B. Spinal muscular atrophy: state-of-the-art and therapeutic perspectives. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Jun;3(2):87-95. Review. S. Government supports a variety of research studies relating to amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker